Sustainable synthesis of tetrasubstituted propargylamines employing a novel, Mn-based catalytic system
Stavros Neofotistos
National and Kapodistrian University of Athens, Greece.
Stavros Neofotistos & Stathis Tonis
Propargylamines serve as useful and versatile substrates for a multitude of organic transformations, as well as promising bioactive molecules. Many catalytic systems have been developed targeting the synthesis of this type of molecules. In this regard, the synthesis of quaternary propargylamines from readily available materials can be achieved via the multicomponent KA2 (Ketone-Amine-Alkyne) reaction. Our research group is currently developing a straight-forward, highly-sustainable and “green” catalytic system based on manganese, which is particularly attractive because of its natural abundance, low cost and relatively low toxicity. This catalytic system works under a very low catalyst loading, without compromising the propargylamine yield. Additionally, it can employ highly-demanding substrates, such as arylamines, significantly expanding the scope of the KA2 reaction.
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