Developing a divergent entry in natural sesquiterpene lactones depending on sequential CH-oxidations
The emergence of preparing diverse natural product scaffolds is firmly associated with the need of our society for more potent and selective biomodulators. In response, nowdays, divergent synthesis utilizing common synthetic scaffolds that can be readily transformed to an array of diverse natural compounds is progressively gaining ground. While sesquiterpene lactones form one of the largest groups of cytotoxic compounds of plant origin, still the true biological potential of this class of compounds as anticancer agents have barely been explored due to the absence of efficient synthetic approaches. The lecture will focus on the identification of their structural polymorphism and on the ways that newly developed CH-oxidations can be applied to produce scalable common scaffolds en route to their divergent synthesis.
