Stavros Neofotistos

Green and sustainable KA² coupling: A novel, highly-efficient, manganese-based catalytic protocol for the synthesis of propargylamines

Propargylamines serve as useful and versatile substrates for a multitude of organic transformations, as well as promising bioactive molecules. Many catalytic systems have been developed targeting the synthesis of this type of molecules. In this regard, the multicomponent KA² (Ketone-Amine-Alkyne) reaction involving the use of sustainable metals has allowed for the synthesis of quaternary propargylamines from readily available materials. Our research group has very recently developed a novel, highly-sustainable and “green” catalytic system based on zinc. We are currently working on an analogous, novel manganese catalytic system, towards expanding the KA² coupling scope further and developing a sustainable, user-friendly, and straightforward catalytic protocol.

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